D.Lorne J. Tyrrell: search on Z-Library

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1

Synthesis and Antiviral Activity of Novel Acyclic Nucleoside Analogues of 5-(1-Azido-2-haloethyl)uracils

Kumar, Rakesh, Sharma, Neerja, Nath, Mahendra, Saffran, Holly A., Tyrrell, D. Lorne J.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

2

Synthesis and Antiviral Activity of Novel 5-(1-Cyanamido-2-haloethyl) and 5-(1-Hydroxy(or methoxy)-2-azidoethyl) Analogues of Uracil Nucleosides

Kumar, Rakesh, Rai, Dinesh, Sharma, Sanjay K., Saffran, Holly A., Blush, Ryan, Tyrrell, D. Lorne J.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

3

Investigating the antiviral role of cell death-inducing DFF45-like effector B in HCV replication

Singaravelu, Ragunath, Delcorde, Julie, Lyn, Rodney K., Steenbergen, Rineke H., Jones, Daniel M., Tyrrell, David Lorne, Russell, Rodney S., Pezacki, John P.

Journal:

Year:

2014

Language:

english

File:

PDF, 837 KB

english, 2014

4

ChemInform Abstract: Novel 5-Vinyl Pyrimidine Nucleosides with Potent anti-Hepatitis B Virus Activity.

Rakesh Kumar, D. Lorne J. Tyrrell

Journal:

Year:

2002

File:

PDF, 30 KB

2002

5

ChemInform Abstract: Nucleic Acid Related Compounds. Part 114. Synthesis of 2,6-(Disubstituted)purine 2′,3′-Dideoxynucleosides [cf. (V)] and Selected Cytotoxic, Anti-Hepatitis B, and Adenosine Deaminase Substrate Activities.

Morris J. Robins, John S. Wilson, Danuta Madej, D. Lorne J. Tyrrell, Wendy P. Gati, R. J. Lindmark, Stanislaw F. Wnuk

Journal:

Year:

2002

File:

PDF, 31 KB

2002

6

HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity In Vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus

Norman M. Kneteman, Anita Y. M. Howe, Tiejun Gao, Jamie Lewis, Dan Pevear, Gary Lund, Donna Douglas, David F. Mercer, D. Lorne J. Tyrrell, Frederick Immermann, Inder Chaudhary, John Speth, Stephen A.

Journal:

Year:

2009

Language:

english

File:

PDF, 248 KB

english, 2009

7

Nucleic acid related compounds. 114. Synthesis of 2,6-(disubstituted)purine 2′,3′-dideoxynucleosides and selected cytotoxic, anti-hepatitis b, and adenosine deaminase substrate activities

Morris J. Robins, R. J. Lindmark, Stanislaw F. Wnukt, John S. Wilson, Danuta Madej, D. Lorne J. Tyrrell, Wendy P. Gati

Journal:

Journal of Heterocyclic Chemistry

Year:

2001

Language:

english

File:

PDF, 112 KB

english, 2001

8

Effect of acyclovir on the uptake of 131 I-labelled 1-(2′fluoro-2′-deoxy-βD-D-arabinofuranosyl)-5-lodouracil in herpes infected cells

Dorothy R. Tovell, Harold P. Yacyshyn, Hemant K. Misra, Edward E. Knaus, Leonard I. Wiebe, John Samuel, M. John Gill, D. Lorne J. Tyrrell

Journal:

Journal of Medical Virology

Year:

1987

Language:

english

File:

PDF, 322 KB

english, 1987

9

High levels of Epstein-Barr virus in the oropharynx: A predictor of disease progression in human immunodeficiency virus infection

Dr. Francisco Diaz-Mitoma, Alejandra Ruiz, Gordon Flowerdew, Stanley Houston, Barbara Romanowski, T. Kovithavongs, Jutta Preiksaitis, D. Lorne Tyrrell

Journal:

Journal of Medical Virology

Year:

1990

Language:

english

File:

PDF, 802 KB

english, 1990

10

Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model

Toshiyasu Kawahara, Christian Toso, Donna N. Douglas, Mahra Nourbakhsh, Jamie T. Lewis, David Lorne Tyrrell, Garry A. Lund, Thomas A. Churchill, Norman M. Kneteman

Journal:

Liver Transplantation

Year:

2010

Language:

english

File:

PDF, 281 KB

english, 2010

11

Impact of calcineurin inhibitors with or without interferon on hepatitis C virus titers in a chimeric mouse model of hepatitis C virus infection

Norman M. Kneteman, Sonal Asthana, Jamie Lewis, Chelcey Dibben, Donna Douglas, Mahra Nourbakhsh, Lorne J. Tyrrell, Garry Lund

Journal:

Liver Transplantation

Year:

2012

Language:

english

File:

PDF, 198 KB

english, 2012

12

Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-Halovinyl)-2′-deoxyuridines

John Samuel, Edward E. Knaus, Leonard I. Wiebe, D. Lorne Tyrrell

Journal:

The International Journal of Applied Radiation and Isotopes

Year:

1984

Language:

english

File:

PDF, 325 KB

english, 1984

13

Synthesis of 131I, 125I, 123I and 82Br labelled 5-halo-1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)uracils

Hemant K. Misra, Edward E. Knaus, Leonard I. Wiebe, D.Lorne Tyrrell

Journal:

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes

Year:

1986

Language:

english

File:

PDF, 325 KB

english, 1986

14

Synthesis and biological properties of (E)-5-(2-[82Br]bromovinyl)-1-(2-deoxy-2-fluoro-β-d-ribofuranosyl)uracil ([82Br]BVFRU)

Takashi Iwashina, Edward E. Knaus, Leonard I. Wiebe, Lihua Xu, D.Lorne Tyrrell, Dorothy R. Tovell

Journal:

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes

Year:

1990

Language:

english

File:

PDF, 370 KB

english, 1990

15

Synthesis and in vitro antiviral activities of 3′-fluoro (or chloro) and 2′,3′-difluoro 2′,3′-dideoxynucleoside analogs against hepatitis B and C viruses

Naveen C. Srivastav, Neeraj Shakya, Michelle Mak, Chao Liang, D. Lorne J. Tyrrell, Babita Agrawal, Rakesh Kumar

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 438 KB

english, 2010

16

Antiviral activity of 2,3′-anhydro and related pyrimidine nucleosides against hepatitis B virus

Naveen C. Srivastav, Michelle Mak, Babita Agrawal, D. Lorne J. Tyrrell, Rakesh Kumar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 264 KB

english, 2010

17

The cell biology of hepatitis C virus

Michael A. Joyce, D. Lorne J. Tyrrell

Journal:

Microbes and Infection

Year:

2010

Language:

english

File:

PDF, 455 KB

english, 2010

18

Novel 5-Vinyl Pyrimidine Nucleosides with Potent anti-Hepatitis B Virus Activity

Rakesh Kumar, D.Lorne J Tyrrell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

19

Critical role of natural killer cells in the rejection of human hepatocytes after xenotransplantation into immunodeficient mice

Toshiyasu Kawahara, Donna N Douglas, Jamie Lewis, Garry Lund, William Addison, David Lorne Tyrrell, Thomas A. Churchill, Norman M. Kneteman

Journal:

Transplant International

Year:

2010

Language:

english

File:

PDF, 447 KB

english, 2010

20

Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers

Hsu, Eric C., Hsi, Belinda, Hirota-Tsuchihara, Masami, Ruland, Jurgen, Iorio, Cathy, Sarangi, Farida, Diao, Jingyu, Migliaccio, Giovanni, Tyrrell, D. Lorne, Kneteman, Norman

Journal:

Nature Biotechnology

Year:

2003

Language:

english

File:

PDF, 1.02 MB

english, 2003

21

Study of the Structure of Replicative Intermediates of HSV-1 DNA by Pulsed-Field Gel Electrophoresis

Alberto Severini, A.Richard Morgan, Dorothy R. Tovell, D.Lorne J. Tyrrell

Journal:

Year:

1994

File:

PDF, 581 KB

1994

22

In vitro activation and differentiation of naïve CD4+ and CD8+ T cells into HCV Core- and NS3-specific armed effector cells: A new role for CD4+ T cells

Deepa K. Krishnadas, Wen Li, Rakesh Kumar, Lorne J. Tyrrell, Babita Agrawal

Journal:

Cellular Immunology

Year:

2009

Language:

english

File:

PDF, 644 KB

english, 2009

23

Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers

John B. Sacci Jr., Uzma Alam, Donna Douglas, Jamie Lewis, D Lorne J. Tyrrell, Abdu F. Azad, Norman M. Kneteman

Journal:

International Journal for Parasitology

Year:

2006

Language:

english

File:

PDF, 309 KB

english, 2006

24

Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery

Carrie S.W. Chong, Min Cao, Winnie W. Wong, Karl P. Fischer, William R. Addison, Glen S. Kwon, D. Lorne Tyrrell, John Samuel

Journal:

Journal of Controlled Release

Year:

2005

Language:

english

File:

PDF, 560 KB

english, 2005

25

An in vitro system for the enzymological analysis of avian hepatitis B virus replication and inhibition in core particles

Sinisa Urban, Severin Urban, D.Lorne Tyrrell

Journal:

Antiviral Research

Year:

2000

Language:

english

File:

PDF, 377 KB

english, 2000

26

A quantitative competitive PCR assay for the covalently closed circular form of the duck hepatitis B virus

William R Addison, Winnie W.S Wong, Karl P Fischer, D.Lorne J Tyrrell

Journal:

Antiviral Research

Year:

2000

Language:

english

File:

PDF, 344 KB

english, 2000

27

Antiviral Activity of Various 1-(2′-Deoxy-β-d-lyxofuranosyl), 1-(2′-Fluoro-β-d-xylofuranosyl), 1-(3′-Fluoro-β-d-arabinofuranosyl), and 2′-Fluoro-2′,3′-didehydro-2′,3′-dideoxyribose Pyrimidine Nucleoside Analogues against Duck Hepatitis B Virus (DHBV) and Human Hepatitis B Virus (HBV) Replication

Srivastav, Naveen C., Shakya, Neeraj, Mak, Michelle, Agrawal, Babita, Tyrrell, D. Lorne, Kumar, Rakesh

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

28

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry

Wilkins, Courtney, Woodward, Jessica, Lau, Daryl T.-Y., Barnes, Amy, Joyce, Michael, McFarlane, Nicola, McKeating, Jane A., Tyrrell, D. Lorne, Gale, Michael

Journal:

AJP Renal Physiology

Year:

2012

Language:

english

File:

PDF, 1.73 MB

english, 2012

29

Identification and characterization of functional CD154 (CD40 ligand) in the Pekin duck

Karl P. Fischer, Sheryl L. Gares, Dakun Wang, D. Lorne Tyrrell, Klaus S. Gutfreund

Journal:

Developmental & Comparative Immunology

Year:

2007

Language:

english

File:

PDF, 387 KB

english, 2007

30

Identification of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) isoforms in the Pekin duck

Qingxia Yao, Karl P. Fischer, Bruce Motyka, Sean Ferland, Lena Li, D. Lorne Tyrrell, Klaus S. Gutfreund

Journal:

Developmental & Comparative Immunology

Year:

2010

Language:

english

File:

PDF, 2.02 MB

english, 2010

31

Genomic structure, molecular characterization and functional analysis of Pekin duck interleukin-10

Qingxia Yao, Karl P. Fischer, D. Lorne Tyrrell, Klaus S. Gutfreund

Journal:

Developmental & Comparative Immunology

Year:

2012

Language:

english

File:

PDF, 2.30 MB

english, 2012

32

Functional changes, increased apoptosis, and diminished nuclear factor–κB activity of myeloid dendritic cells during chronic hepatitis C infection

Li Zhao, Justin Shields, D. Lorne Tyrrell

Journal:

Human Immunology

Year:

2010

Language:

english

File:

PDF, 2.41 MB

english, 2010

33

HCV-core and NS3 antigens play disparate role in inducing regulatory or effector T cells in vivo: Implications for viral persistence or clearance

Deepa K. Krishnadas, Wen Li, Rakesh Kumar, D. Lorne Tyrrell, Babita Agrawal

Journal:

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

34

Immunogenicity and protective efficacy of a DNA vaccine encoding a chimeric protein of avian influenza hemagglutinin subtype H5 fused to CD154 (CD40L) in Pekin ducks

Qingxia Yao, Karl P. Fischer, Lena Li, Babita Agrawal, Yohannes Berhane, D. Lorne Tyrrell, Klaus S. Gutfreund, John Pasick

Journal:

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

35

Peptide vaccination is superior to genetic vaccination using a recombineered bacteriophage λ subunit vaccine

Brad S. Thomas, Sandra Nishikawa, Kenichi Ito, Puja Chopra, Navneet Sharma, David H. Evans, D. Lorne J. Tyrrell, Oliver F. Bathe, Derrick E. Rancourt

Journal:

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

36

P.354 HBV specific acyclic pyrimidine nucleosides: synthesis and anti-HBV activity of 5- and/or 6-substituted analogs of 1-[(2-hydroxyethoxy)methyl] uracils

R. Kumar, W. Semaine, M. Johar, D. Lorne, J. Tyrrell, B. Agrawal

Journal:

Journal of Clinical Virology

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

37

DNase-Mediated Single-Cycle Selection of Aptamers for Proteins Blotted on a Membrane

Liu, Yanming, Wang, Chuan, Li, Feng, Shen, Shengwen, Tyrrell, D. Lorne J., Le, X. Chris, Li, Xing-Fang

Journal:

Analytical Chemistry

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

38

Idiopathic colitis associated with scrotal cellulitis

Brian D. O'Brien, Alan B.R. Thomson, D. Lorne Tyrrell, Lawrence D. Jewell

Journal:

The Journal of Pediatrics

Year:

1979

Language:

english

File:

PDF, 295 KB

english, 1979

39

61 Inducing apoptosis in hepatitis C infected Alb-UPA/SCID mice with gene therapy mechanisms

Belinda Hsi, Eric Hsu, Chris Richardson, Lorne Tyrrell, Norman Kneteman

Journal:

Year:

2003

Language:

english

File:

PDF, 122 KB

english, 2003

40

251 Establishing the validity of the ALB-UPA/SCID mouse model of HCV in the testing of anti-viral therapies

Belinda Hsi, Daniel Schiller, Karl Fischer, Tiejun Gao, David Bigam, Lorne Tyrrell, Norman Kneteman

Journal:

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

41

Lamivudine resistance in hepatitis B: mechanisms and clinical implications

Karl P Fischer, Klaus S Gutfreund, D.Lorne Tyrrell

Journal:

Drug Resistance Updates

Year:

2001

Language:

english

File:

PDF, 257 KB

english, 2001

42

Inhibition of Hepatitis B Virus (HBV) Replication by Pyrimidines Bearing an Acyclic Moiety: Effect on Wild-Type and Mutant HBV

Semaine, Wassila, Johar, Monika, Tyrrell, D. Lorne J., Kumar, Rakesh, Agrawal, B.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 73 KB

english, 2006

43

Design and Synthesis of Novel 5-Substituted Acyclic Pyrimidine Nucleosides as Potent and Selective Inhibitors of Hepatitis B Virus

Kumar, Rakesh, Nath, Mahendra, Tyrrell, D. Lorne J.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 107 KB

english, 2002

44

Myeloid Dendritic Cells Can Kill T Cells During Chronic Hepatitis C Virus Infection

Zhao, Li, Tyrrell, David Lorne

Journal:

Viral Immunology

Year:

2013

Language:

english

File:

PDF, 983 KB

english, 2013

45

An Inactivated Hepatitis C Virus Vaccine on the Horizon?

Houghton, Michael, Law, John Lokman, Tyrrell, D. Lorne

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 100 KB

english, 2013

46

Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication

Nasheri, Neda, Joyce, Michael, Rouleau, Yanouchka, Yang, Pengyu, Yao, Shao, Tyrrell, D. Lorne, Pezacki, John Paul

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

47

Detailed Computational Study of the Active Site of the Hepatitis C Viral RNA Polymerase to Aid Novel Drug Design

Barakat, Khaled H., Law, John, Prunotto, Alessio, Magee, Wendy C., Evans, David H., Tyrrell, D. Lorne, Tuszynski, Jack, Houghton, Michael

Journal:

Journal of Chemical Information and Modeling

Year:

2013

Language:

english

File:

PDF, 1.92 MB

english, 2013

48

Human serum activates CIDEB-mediated lipid droplet enlargement in hepatoma cells

Singaravelu, Ragunath, Lyn, Rodney K., Srinivasan, Prashanth, Delcorde, Julie, Steenbergen, Rineke H., Tyrrell, D. Lorne, Pezacki, John P.

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

49

Progress towards a hepatitis C virus vaccine

Man John Law, Lok, Landi, Abdolamir, Magee, Wendy C, Lorne Tyrrell, D, Houghton, Michael

Journal:

Emerging Microbes & Infections

Year:

2013

Language:

english

File:

PDF, 627 KB

english, 2013

50

Hepatitis C virus and microRNAs: miRed in a host of possibilities

Singaravelu, Ragunath, Russell, Rodney S, Tyrrell, D Lorne, Pezacki, John Paul

Journal:

Current Opinion in Virology

Year:

2014

Language:

english

File:

PDF, 654 KB

english, 2014